Common distal elements orchestrate CIITA isoform-specific expression in multiple cell types
نویسندگان
چکیده
منابع مشابه
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The transcriptional coactivator CIITA regulates MHC class II genes. In the mouse, CIITA is expressed from three distinct promoters (pI, pIII, and pIV) in a developmental and cell type-specific manner with pIII being responsible for B lymphocyte-specific expression. Although the promoter proximal sequences that regulate CIITA in B cells have been described, nothing is known about additional dist...
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The Major Histocompatibility Complex (MHC) class II transactivator (CIITA) acts as a master switch to activate expression of the genes required for MHC-II antigenpresentation. During B-cell to plasma cell differentiation, MHC-II expression is actively silenced but the mechanism has been unknown. In plasma cell tumors such as multiple myeloma the repression of MHC-II is associated with the loss ...
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ژورنال
عنوان ژورنال: Genes & Immunity
سال: 2014
ISSN: 1466-4879,1476-5470
DOI: 10.1038/gene.2014.49